周红

姓名：周红  博士

职称职务：医学院医学检验系专任教师

研究方向：主要利用理论模拟计算，从事面向生命科学、医学、药学、材料等多学科交叉领域的理论研究。在肿瘤免疫领域的蛋白质互作、抗原肽优化设计，新型纳米材料的理性设计、及纳米材料与小分子药物防治阿尔茨海默病的机理方面开展诸多基础性研究

主讲课程：《医学免疫学》

发表代表性论文：

在国际相关领域主流期刊已发表SCI论文15篇，其中第一/共同第一作者8篇

1. Yin, X.^#; Zhou, H.^#;, Cao, T.^#, Yang, X.; Meng, F. Dai, X; Wang, Y; Li, S.; Zhai, W.; Yang, Z.*; Chen, N.*; Zhou, R.*, Rational Design of Dual-Functionalized Gd@_C82 Nanoparticles to Relieve Neuronal Cytotoxicity in Alzheimer‘s Disease via Inhibition of Aβ Aggregation, Acs Nano. 2024, 18 (24), 15416-15431. (IF=17.1, 材料科学1区Top, 共同第一作者)

2. Zhou, H.; Chan, K. C.; Buratto, D.; Zhou, R.* The rigidity of a structural bridge on HLA-I binding groove explains its differential outcome in cancer immune response. Int. J. Biol. Macromol. 2023, 127199. (IF=8.2, 化学1区Top, 第一作者)

3. Zhu, Q.^#; Zhou, H.^#; Wu, L.; Lai, Z.; Geng, D.; Yang, W.; Zhang, J.; Fan, Z.; Qin, W.; Wang, Y.; Zhou, R.*; Yi, W.* O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1. Nat. Chem. Biol. 2022, 18, 1087-1095. (IF=14.8, 生物学1区Top, 共同第一作者)

4. Yin, X.^#; Zhou, H.^#; Zhang, M.^#; Su, J.; Wang, X.; Li, S.; Yang, Z.*; Kang, Z.*; Zhou, R.*, C₃N nanodots inhibits Abeta peptides aggregation pathogenic path in Alzheimer's disease. Nat. Commun. 2023, 14, 5718. (Featured article in Editors' Highlight (Structural biology, biochemistry and biophysics); featured article in the subject of protein aggregation within Nature Communications) (IF=16.6, 综合性期刊1区Top, 共同第一作者)

5. Zhou, H.^#, Li, Y.^#, Yang, Y., Liu, S., Yang, Z.* Lanosterol reduces the aggregation propensity of ultraviolet-damaged human γD-crystallins: a molecular dynamics study. Phys. Chem. Chem. Phys. 2021, 23, 13696-13704. (IF=3.945, 化学2区Top，第一作者)

6. Zhou, H., Liu, S., Yin, X., Li, Z., Yang, Z.*, Zhou, R.* Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains. Biophys. J. 2019, 116, 1907-1917. (IF=3.854, 生物学2区Top, 第一作者)

7. Zhou, H.^#, Yang, Z.^#, Tian, X.^#, Chen, L., Lee, S., Huynh, T., Ge, C., Zhou, R.* Lanosterol Disrupts the Aggregation of Amyloid-beta Peptides. ACS Chem. Neurosci. 2019, 10, 4051-4060. (IF=4.486, 药物化学2区, 第一作者)

8. Zhou, H., Liu, S., Shao, Q., Ma, D., Yang, Z.*, Zhou, R.* Mechanism by which DHA inhibits the aggregation of KLVFFA peptides: A molecular dynamics study. J. Chem. Phys. 2018, 148, 115102. (IF=2.997, 物理2区Top, 第一作者)

9. Tang, X.^#, Zhang, S.^#, Zhou, H., Zhou, B., Liu, S., Yang, Z.* The role of electrostatic potential polarization in the translocation of graphene quantum dots across membranes. Nanoscale. 2020, 12, 2732-2739. (IF=6.7)

10. Ge, X. C.^#; Dai, X.^#; Zhou, H.; Yang, Z. X.; Zhou, R. H. Stabilization of Open-Shell Single Bonds within Endohedral Metallofullerene. Inorg. Chem. 2020, 59, 3606-3618. (IF=4.6)

11. Xie, X., Hou, Z., Duan, G., Zhang, S., Zhou, H., Yang, Z., Zhou, R.* Boron nitride nanosheets elicit significant hemolytic activity via destruction of red blood cell membranes. Colloids and Surfaces B: Biointerfaces. 2021, 203, 111765. (IF=5.8)

    [12] Liu, S.^#, Yin, X.^#, Zhou, H., Zhou, B., Shao, Q., Yang, Z.*, Zhou, R.* Different platinum crystal surfaces show very distinct protein denaturation capabilities. Nanoscale. 2019, 11, 19352-19361. (IF=6.7)

    [13]  Yin, X., Liu, S., Perez-Aguilar, J., Zhou, H., Shao, Q., Yang, Z.*, Zhou, R.* Different protonated states at the C-terminal of the amyloid- peptide modulate the stability of S-shaped protofibril. J. Chem. Phys. 2019, 150, 185102. (IF=4.4)

    [14] Gu, Z., Yang, Z., Luan, B., Zhou, X., Hong, L., Zhou, H., Luo, J., Zhou, R.* Membrane Insertion and Phospholipids Extraction by Graphyne Nanosheets. J. Phys. Chem. C. 2017, 121, 2444-2450. (IF=3.7)

    [15] Gu, Z., Yang, Z., Wang, L., Zhou, H., Jimenez-Cruz, C. A., Zhou, R.* The role of basic residues in the adsorption of blood proteins onto the graphene surface. Sci. Rep. 2015, 5, 10873. (IF=4.6)

主持或参与课题：

科技部，国家重点研发计划，2021YFF1200404，蛋白质结构预测算法研究及蛋白质设计应用—《分子动力学模拟和高精度结构修正研究》子课题，2021-12 至2024-11，455.76万元，在研，参与

专利：

尹秀华，刘胜堂，周红，李友云，杨再兴，谌宁，周如鸿. (2019) 改性内嵌金属富勒烯及其制备方法与应用，公开号: CN110179822A.