姓名：魏永伟 博士，硕士生导师
职称职务：副教授，基础医学部专任教师
学术兼职：中国免疫学会会员，美国病毒学会会员
研究方向：病毒学，微生物学
主讲课程：《分子生物学》、《生理学》
发表代表性论文：
[1]Zhang X, Shen W, Xu C, Wang Y, Xu H, Liu X, Wei Y（通讯作者）.Discovery of a
novel Piscanivirus in yellow catfish (Pelteobagrus fulvidraco) in China.Infect
Genet Evol. 2019 Oct;74:103924. doi: 10.1016/j.meegid.2019.103924
[2]Wei Y, Fan D, Chen J. The mussel Mytilus edulis L. as an important reservoir
of infectious hypodermal and hematopoietic necrosis virus(IHHNV). Aquaculture
Research, 2017, 2017, 48, 1346–1350.
[3]Wei Y, Fan D, Chen J.Development of an overlapping PCR method to clone the
full genome of infectious hypodermal and hematopoietic necrosis virus (IHHNV).
J. Virol Methods. 2015,224:16-19. SCI
[4] Wei Y, Zhang Y, Cai H, Mirza AM, Iorio RM, Peeples ME, Niewiesk S, Li J. Roles
of the putative integrin-binding motif of the human metapneumovirus fusion (f)
protein in cell-cell fusion, viral infectivity, and pathogenesis. J.
Virol.2014,88(8):4338-4352.
[5] Wei Y, Kurtis F., Yao X.,Anne M. Mirza, Ronald M. Iorio, Cai H. and Li J.
Localization of a region in the fusion (F) protein of avian metapneumovirus that
modulates fusion. J. Virol. 2012,86:11800-11814.
[6] Wei Y,Xu H., Zheng J,Chu W, Xu H, Yu X, Yu L. Reassortant infectious bursal
disease virus isolated in China.Virus Res., 2008,131:279–282.
[7] Wei Y, Li J., Zheng J., Xu H., Li L., Yu L. Genetic reassortment of infectious
bursal disease virus in nature.Biochem. Biophys. Res. Commun.,
2006,350:277–287.
[8] Sun J,Wei Y(共同第一作者), Rauf A, Zhang Y, Ma Y, Zhang X, Shilo K, Yu Q, Saif
YM, Lu X, Yu L, Li J. Methyltransferase-defective avian metapneumovirus vaccines
provide complete protection against challenge with the
homologousColoradostrain and the heterologousMinnesotastrain. J. Virol.
2014,88(21):12348-12363.
[9] Zhang Y,Wei Y(共同第一作者),Li J. Development and optimization of direct plaque assay for metapneumovirus. Journal of Virological Methods. 2012, 185:61-68.
[10] Wang F,Wei Y(共同第一作者), Zhu C, Huang X, Xu Y, Yu L, Yu X. Novel parvovirus sublineage in the family of Parvoviridae. Virus Genes, 2010, 41:305–308.
[11]Zhang Y,Wei Y, Zhang X, Cai H, Niewiesk S, Li J. Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase. J. Virol. 2014,88(19):11411-11429.
[12]Ma Y,Wei Y, Zhang X, Zhang Y, Cai H, Zhu Y, Shilo K, Oglesbee M, Krakowka S, Whelan SP, Li J. mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo. J Virol. 2014,88(5):2913-2926.
[13] Zhang X,Wei Y, Ma Y, Hu S, Li J. Identification of aromatic amino acid residues in conserved region VI of the large polymerase of vesicular stomatitis virus is essential for both guanine-N-7 and ribose 2'-O methyltransferases.Virology, 2010,408:241-252.
[14] Li L.,Wei Y., Huang Y.,Yu L.Generation of VP5 deficient mutant of infectious bursal disease virus strain HZ2.Chinese Science Bulletin,2006,51(15):1909-1912.
[15]Liu Y.,Wei Y., Wu X., Yu L. Preparation of ChIL-2 and IBDV VP2 fusion protein by baculovirus expression system.Cellular & Molecular Immunology,2005, 2(3):1-5.
[16] Chu W.,Wei Y.,Qian R., Yu X. , Yu L.Characterization of the 5′-to- 5′linked adult α- and β-globin genes from three sciaenid species,Pseudosciaena crocea,Sciaenops ocellatus and Nibea miichthioides.Comparative Biochemistry and Physiology,Part D,2006,(3):319-327.
[17] Ma Y, Duan Y,Wei Y, Liang X, Niewiesk S, Oglesbee M, Li J. Heat shock protein 70 enhances mucosal immunity against human norovirus when coexpressed from a vesicular stomatitis virus vector. JVirol. 2014 ,88(9):5122-5137.
[18]Zhang Y, Sun J,Wei Y, Li J. A Reverse Genetics Approach for the Design of Methyltransferase-Defective Live Attenuated Avian Metapneumovirus Vaccines. Methods Mol Biol. 2016,1404:103-21.
[19]Mao Z, Yu L, You Z,Wei Y, Liu Y. Cloning, expression and immunogenicty analysis offive outer membrane proteins ofVibrio parahaemolyticuszj2003. Fish & Shellfish Immunology, 2007,23:567-575.
[20]Mao Z, Yu L, You Z,Wei Y, Liu Y. Expression and Immunogenicity Analysis of Two Iron-regulated Outer Membrane Proteins ofVibrio parahaemolyticus. Acta Biochimica et Biophysica Sinica, 2007,39(10):763-769.
[21]Qian,R Xiao Z, Zhang C,Chu W, Wang L, Zhou H,Wei,Y,Yu L. A conserved outer membrane protein as an effective vaccine candidate fromVibrio alginolyticus. Aquaculture, 2008,278:5-9.
[22] Qian R,Chu W, Mao Z, Zhang C,Wei Y, Yu L.Expression, Characterization and Immunogenicity of a Major Outer MembraneProtein from Vibrio alginolyticus,Acta Biochimica et Biophysica Sinica, 2007,39(3):194–200.
主持课题：
1. 国家自然科学基金（编号31402218 2015.01-2017.12）
2. 浙江省自然科学基金（编号LY 14C 180001，2014.04-2016.12）
3. 教育部留学回国人员基金（编号511500040，2014.09-2016.09）
4. 浙江省教育厅科研计划（编号Y201430861，2014.10-2016.10）
5. 宁波市自然科学基金（编号 2014A 610182，2014.02-2015.12）
6. 宁波市自然科学基金（编号 2017A 610281，2016.09-2018.09）
参与国际课题：
1. Messenger RNA Capping And Methylation In Pneumoviruses（Funding source: NIH，R01AI090060）美国NIH项目，主要参加人
2. Methyltransferase-defective viruses as live vaccine candidates for avianmetapneumovirus: a jump from theory to practice.” （Funding source:USDA，2010-65119-20602）。美国USDA项目，主要参加人
专利：
1.“Novel live attenuated vaccines for human metapneumovirus” (Tech ID # 2013-030) Inventor: Li J., Wei Y. and Zhang Y. 。
2."METAPNEUMOVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS" Reference No. :RINCH 2014-004-02, Inventor: Li J., Wei Y. and Zhang Y.
