姓名：胡亚杰  博士研究生

职称职务：医学院基础医学部专任教师

研究方向：脂肪组织产热与肥胖调控、衰老机制与干预

主讲课程：《药理学》等

发表代表性论文：

1. Hu Y, Zhao J, Xiao C, et al. Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice. Cell Mol Biol Lett. 2026;31(1):47.（SCI一区Top，IF=12.2)

2. Hu Y, Xue X, Han T, et al. An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening. Commun Biol. 2025;8(1):1316. （SCI一区Top，IF=5.8)

3. Hu Y, Zhao J, Xu S, et al. Hypobaric hypoxia disrupts brown adipose thermogenic function in mice via Plin2 upregulation. Diabetes Obes Metab. 2026;28(3):1874-1885. （SCI二区，IF=6.1)

4. Xiao C#, Hu Y#, Liu J, et al. SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice. Cell Death Differ. Published online July 1, 2026. （SCI一区Top，IF=13.6)

5. Xiao C#, Su Z#, Zhao J#, Hu Y, He M, Xu S, Chen R, Xu J, Chang J*, Lin C*, Liu X*, Chen W*. SEMA3E promotes beige adipocyte differentiation and thermogenesis via β-catenin signaling in mice. Apoptosis. 2026 Feb 2;31(2):63.（SCI一区Top，IF=9.0)

6. Chen H, Xu J, Huang Q, Zhao J, Hu Y, Wang C, Zhong W, Zhang Y, Fan C*, Chang J*, Liu X*. Kif23 Promotes Myocardial Fibrosis by Suppressing Ces1d-Dependent Lipid Metabolism. Hypertension. 2026 Jan;83(1):116-129.（SCI一区ToP，IF=9.8)

7. Wang C, Chen WG, Chen H, Zhao J, He J, Hu Y, He M, Zhang Y, Lin CS*, Chang J*, Liu X*. Exercise improves hypobaric hypoxia-induced skeletal muscle dysfunction via Sirt1-Mediated myotube and mitochondrial remodeling. J Adv Res. 2026 May;83:423-437.（SCI一区，IF=17.1)

8. Li Y#, He M#, Xu J, Liu J, Xiao C, Hu Y, Chen H, Chang J*, Liu X*. Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases. FASEB J. 2025 Jun 30;39(12):e70696.（SCI二区，IF=4.3)

9. Huang Q#, Zhong W#, Chen R, Xu S, Wang H, He J, Hu Y, Chen H, Fan C*, Liu X*. SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway. Cell Biosci. 2025 Nov 5;15(1):153.（SCI二区，IF=6.5)

10. Xiao C#, Su Z#, Zhao J, Tan S, He M, Li Y, Liu J, Xu J, Hu Y, Li Z*, Fan C*, Liu X*. Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis. Cell Mol Biol Lett. 2025 Mar 31;30(1):38.（SCI一区Top，IF=12.2)

主持或参与课题：

参与国家重点研发计划项目“极端状态下机体能量代谢调控和组织稳态”。

参与上海市科学技术委员会项目“治疗脑卒中的化药一类新药MT-8的临床前开发研究”。

参与上海市自然科学基金项目“选择性SET7/9抑制剂的设计优化及缺血性脑损伤保护机制”。