姓名:刘正 博士
职称职务:讲师、副主任法医师,基础医学部教师
荣誉:2018年度校优秀教师、2020年度优秀农工党党员
社会兼职:绍兴文理学院司法鉴定中心法医毒物司法鉴定人;中国睡眠研究会睡眠生理和药理专业委员;浙江省生理科学会理事;绍兴市农工民主党资源与环境委员会委员;中国神经科学会会员;中国药理学会会员。 Phytomedicine (IF=6.7), Food & Function (IF=5.1), Gut Microbes (IF=12.2)等SCI TOP期刊审稿专家。
研究方向:抑郁性睡眠障碍的神经生物学机制及干预;酒精中毒的机制及药物保护作用;营养与疾病因果关系的孟德尔随机化研究;人工智能与重大慢性疾病治疗效果的预测研究。
主讲课程:《药理学》、《人体机能学》、《睡眠与健康》、《血液与心血管系统》
代表性论文(第一或通讯作者):
[1]. Zhang, Z., et al., Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease. Biomedicine & Pharmacotherapy, 2024. 174: p. 116567. (中科院一区,TOP, IF=7.5)
[2]. Wu, M., et al., Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis. Biomedicine & Pharmacotherapy, 2024. 178: p. 117228. (中科院一区,TOP, IF=7.5)
[3]. Guo, S., et al., Comparative efficacy of interventional therapies and devices for coronary in-stent restenosis: A systematic review and network meta-analysis of randomized controlled trials. Heliyon, 2024. 10(6): p. e27521.
[4]. Jing, W., et al., Neuropsychiatric sequelae after liver transplantation and their possible mechanism via the microbiota–gut–liver–brain axis. Biomedicine & pharmacotherapy, 2023. 163: p. 114855-114855. (中科院一区,TOP, IF=7.5)
[5]. Bi, C., et al., Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases. Heliyon, 2023. 9(5): p. e15609.
[6]. Han, W., et al., Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease. PeerJ, 2023. 11: p. e15977.
[7]. Bi, C., et al., Botanical characteristics, chemical components, biological activity, and potential applications of mangosteen. PeerJ, 2023. 11: p. e15329.
[8]. Bi, C., et al., The microbiota–gut–brain axis and its modulation in the therapy of depression: Comparison of efficacy of conventional drugs and traditional Chinese medicine approaches. Pharmacological Research, 2022. 183: p. 106372. (中科院一区,TOP, IF=9.3)
[9]. Lv, T., et al., Evaluation of Melatonin Therapy in Patients with Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis. Oxid Med Cell Longev, 2022. 2022: p. 4610522.
[10]. Ye, M., et al., Efficacy of cognitive therapy and behavior therapy for menopausal symptoms: a systematic review and meta-analysis. Psychol Med, 2022. 52(3): p. 433-445. (中科院一区,TOP, IF=6.9)
[11]. Hu, B., et al., Meta-analysis of sleep deprivation effects on depression in rodents. Brain Res, 2022. 1782: p. 147841.
[12]. Lv, T., et al., Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 2021. 120: p. 159-172. (中科院一区,TOP, IF=8.2,它引33次)
[13]. Bi, C., et al., Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer. Front Cell Dev Biol, 2021. 9: p. 702414. (中科院二区)
[14]. Hu, B., et al., Meta-Analysis of Sleep Deprivation Effects on Patients With Depression. Front Psychiatry, 2021. 12: p. 783091.
[15]. Luo, F., et al., Efficacy of Cognitive Behavioral Therapy on Mood Disorders, Sleep, Fatigue, and Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis. Front Psychiatry, 2021. 12: p. 793804.
[16]. Chen, J., et al., Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters. Toxicology, 2020. 429: p. 152338. (中科院二区,它引50次)
[17]. Si, W., et al., Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms. Revista Brasileira de Farmacognosia, 2020. 30(6): p. 780-788.
[18]. Li, Q., et al., Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO. Acta Biochim Biophys Sin (Shanghai), 2018. 50(3): p. 246-253. (中科院二区,它引62次)
[19]. Ye, M., et al., A meta-analysis of the efficacy of cognitive behavior therapy on quality of life and psychological health of breast cancer survivors and patients. Psychooncology, 2018. 27(7): p. 1695-1703.(中科院二区,它引73次)
[20]. 叶猛飞等, 浙江省农村老年人睡眠质量及其影响因素. 中国老年学杂志, 2016. 36(05): 第1183-1185页.(被引39次)
[21]. YE, M., et al., Flos Albiziae aqueous extract and its active constituent quercetin potentiate the hypnotic effect of pentobarbital via the serotonergic system. Biomedical Reports, 2015. 3(6): p. 835-838.
[22]. Liu, Z., et al., Safranal Enhances Non-Rapid Eye Movement Sleep in Pentobarbital-Treated Mice.
CNS Neuroscience & Therapeutics, 2012. 18(8): p. 623-630. (中科院一区,IF=4.8,它引23次)
[23]. 刘正, 俞朝阳,张剑, 临床医学专业药理学《糖皮质激素》说课设计. 西北医学教育, 2012. 20(06): 第1203-1205页.
[24]. 刘正, 刘学红,张剑, 药理学教学中的记忆困难及应对措施. 基础医学教育, 2012. 14(12): 第942-944页.
主持或参与课题:
1. 基于circRNAs组学与蛋白组学对抑郁症生物标记物及预测模型构建的研究,浙江省医药卫生科技计划项目 (No 2024KY484), 2024.1-2026.12, 参与,在研。
2. 基于蛋白组学与转录组学对精神分裂症生物标记物及预测模型构建的研究,绍兴市卫生健康科技计划项目(No 2023SKY073),2024.1-2026.12, 参与,在研。
3. 基于16S rRNA检测肠道菌群早期诊断AD的研究, 浙江省卫生健康委 (No 2023KY1271),2023.1-2025.12,参与,在研。
4. 基于脑-肠轴途径治疗抑郁症患者及其机制研究,浙江省卫生健康委(No 2020KY332), 2020.1-2022.12,参与,结题。
5. miR-338-3p 靶向 SIRT6 调节肝癌细胞凋亡逃逸机制研究,绍兴市科技局项目,(No 2020A13061),2021.01.31—2023.12.31, 参与,结题。
6. tDCS对围绝经期抑郁症患者脑电生理及睡眠脑波影响的研究,浙江省卫计委(NO.2019KY724), 2019.1-2021.12, 参与,结题。
7. Roux-en-Y胃转流术中胆汁改道对Na+_葡萄糖同向转运体(SGLT1)的调节作用机制研究,绍兴市科技局(No 2017B70050),2017.12-2019.12, 参与,结题。
8.合欢花活性成分槲皮素的催眠作用及机制研究,绍兴市科技局,2014-2016,主持,结题。
9.中药单体对睡眠作用的研究,绍兴文理学院博士科研启动基金,2012.9-2016.9,主持,结题。
10.构建创新性高素质人才药理学教学模式研究,绍兴市教育局,2012.02-2014.2,主持,结题。
11.上海产西红花催眠作用的有效成分和机制研究 (No. 09JC1402500), 上海市科委重点课题, 2009.9-2011.9, 参与,结题。
12. 防治精神性、心血管疾病及抗病毒感染药临床前药效评价平台建设 (No. 2009ZX09303),科技部重大专项,2009.6-2011.6,参与,结题。
13. 脑血栓候选新药磷脂酰丝氨酸脑靶向脂质体的实验研究 (No.30800360),国家自然科学基金,2009.1-2011.12,参与,结题。
14. 改革实验教学模式提高学生创新思维能力,省教育科学规划课题,2008.1-2009.12,参与,结题。
15. 浙江省课程思政教学示范课程《药理学》,浙江省教育厅,2022.1-2024.1,参与,结题。
16. 浙江省一流课程《药理学》,浙江省教育厅,2022.1-2024.1,参与,结题。
17. 越地元素+OBE+O2O模式在通识课中课程思政的改革与实践,绍兴市教育局,2023.1-2024.1,参与,结题。
18. 越地诗书画的中药之美,校级思政课程,2022.1-2023.1,参与,结题。
参编教材与专利:
1.《人体机能学》,刘丽华主编,浙江大学出版社, 2010年1月出版。
2. 唾液酒精浓度检测仪,2015, 实用新型专利,授权号ZL2014204407760。
获奖:
2016年度全国高等学校自然科学奖二等奖(6/8), 教育部。
2021年度中国食品工业协会科学技术一等奖(15/15),中国食品工业协会。
2021年校级教学成果二等奖(5/5),绍兴文理学院。